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KMID : 0357920100440040431
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Korean Journal of Pathology
2010 Volume.44 No. 4 p.431 ~ p.434
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Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast
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Kim Ga-Eon
Kim Young
Jeong Eun-Hui
Kim Jo-Heon
Park Min-Ho
Lee Ji-Shin
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Abstract
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Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-β, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-α, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.
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KEYWORD
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Breast, Fibroadenoma, Muscle cells, Metaplasia
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